Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2.

稀释比  WB:1/500-1/1000; IHC:1/50-1/100; IF: 1/50-1/200; IP:1/20

Western blot

Western blot analysis of MEK1/2 in K562, C6, 3T3, HeLa lysates using MEK1/2 antibody.

Immunocytochemistry

Immunocytochemistry analysis of MEK1/2(green) in HeLa using MEK1/2 antibody, and DAPI(blue).

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded Human colon cancer using MEK1/2 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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