QNZ (EVP4593, EVP-4593)，一种可渗透细胞的喹唑啉化合物，是NF-κB途径的抑制剂，抑制NF-κB转录激活，IC₅₀为11 nM，具有抗炎活性。EVP4593也能抑制小鼠脾细胞中LPS刺激的TNF-α产生，IC₅₀为7 nM。

参考文献

[1] Tobe M, et al. Discovery of quinazolines as a novel structural class of potent inhibitors of NF-kappa B activation. Bioorg Med Chem. 2003 Feb 6;11(3):383-91.

[2] Armstrong SJ, et al. Laminin activates NF-kappaB in Schwann cells to enhance neurite outgrowth. Neurosci Lett. 2008 Jul 4;439(1):42-6.

[3] Armstrong SJ, et al. Dexamethasone inhibits lipopolysaccharide-induced hydrogen sulphide biosynthesis in intact cells and in an animal model of endotoxic shock. Neurosci Lett. 2008 Jul 4;439(1):42-6.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。