Tegatrabetan (BC2059, BC-2059, BC 2059, Tegavivint)是β-Catenin拮抗剂。Tegatrabetan破坏β-catenin与scaffold protein transducin β-like 1 (TBL1)的结合，抑制蛋白酶体降解，下调β-catenin胞核表达水平。

参考文献

[1] Fiskus W, et al. Pre-clinical efficacy of combined therapy with novel β-catenin antagonist BC2059 and histone deacetylase inhibitor against AML cells. Leukemia. 2015 Jun;29(6):1267-78.

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