IDE1 (IDE-1, IDE 1, Definitive Endoderm 1 Inducer),是一种定形内胚层诱导物,可能会被用于器官移植等方面。IDE-1可诱导小鼠和人的胚胎干细胞形成定形内胚层,EC50相应分别为125 nM和223 nM。
参考文献
[1]. Hoveizi E, et al. Definitive endoderm differentiation of human-induced pluripotent stem cells using signaling molecules and IDE1 in three-dimensional polymer scaffold. J Biomed Mater Res A. 2014 Nov;102(11):4027-36.
[2]. Borowiak M, et al. Small molecules efficiently direct endodermaldifferentiation of mouse and human embryonic stem cells. Cell Stem Cell. 2009 Apr 3;4(4):348-58.
[3]. Filby CE, et al. Stimulation of Activin A/Nodal signaling isinsufficient to induce definitive endoderm formation of cord blood-derivedunrestricted somatic stem cells. Stem Cell Res Ther. 2011 Apr 4;2(2):16.
冰袋运输。粉末直接保存于-20℃,有效期2年。建议分装后-20℃干燥保存,避免反复冻融。