Cryptotanshinone (Tanshinone c, CTS, Cryptotanshinon),又称隐丹参酮,是来自丹参的根中的脂溶性二萜醌类化合物,具有抗肿瘤、抗炎、抗菌活性。Cryptotanshinone也是STAT3抑制剂,IC50值为4.6 μM,对STAT3 Tyr705磷酸化抑制活性强,但对STAT3 Ser727抑制效果弱,此外,不抑制STAT1和STAT5。
参考文献
1.Shin DS, et al. Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells. Cancer Res. 2009;69(1):193-202.
2.Huang Y, et al. Cryptotanshinone reverses ovarian insulin resistance in mice through activation of insulin signaling and the regulation of glucose transporters and hormone synthesizing enzymes. Fertil Steril. 2014;102(2):589-596.e4.
3.Ge Y, et al. Cryptotanshinone acts synergistically with imatinib to induce apoptosis of human chronic myeloid leukemia cells. Leuk Lymphoma. 2015;56(3):730-8.
4.Kim EJ, et al. Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase. Mol Pharmacol. 2007;72(1):62-72.
冰袋运输。粉末直接保存于-20℃,有效期2年。建议分装后-20℃避光保存,避免反复冻融。