Niclosamide (BAY2353, BAY-2353, Niclocide, NSC 178296, NSC178296),又称氯硝柳胺、灭绦灵、贝螺杀或杀螺胺,是一种驱虫药,能抑制DNA复制,也是STAT3抑制剂(IC50: 0.7 μM),但不抑制其他STAT家族成员的激活。
参考文献
1.Ren, X, et al., Identification of niclosamide as a new small-molecule inhibitor of the STAT3 signaling pathway. ACS Medicinal Chemistry Letters. 2010;1(9):454-459.
2.Wu CJ, et al. Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide. Antimicrob Agents Chemother. 2004;48(7):2693-6.
3.Chen, M, et al., The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling. Biochemistry. 2009;48(43):10267-7.
3.Jin Y, et al. Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen species. Cancer Res. 2010;70(6): 2516-27.
冰袋运输。粉末直接保存于-20℃,有效期2年。建议分装后-20℃避光保存,避免反复冻融。