Yeasen胎牛血清（特级），经3次100 nm过滤和支原体、病毒筛查，经过严格检验测试后全自动化罐装，规范化生产，品质保证，含有丰富的细胞生长所需的营养成分，适用于培养大部分常规细胞系。
| 中文别名（Chinese Synonym） | 胎牛血清（特级） |
| 英文别名（English Synonym） | Fetal Bovine Serum Gold |
| 内毒素水平 | ≤5 EU/mL |
| 血红蛋白含量 | ≤0.02%(w/v) |
| 支原体检测 | 阴性 |
| 灭菌处理 | 三次100 nm过滤 |
产品选购指南
1. 适用于绝大多数常规细胞的培养，如常规肿瘤细胞、规模化生产细胞（293T、CHO、VERO等）、免疫细胞（RAW264.7、THP-1等）。其他娇贵细胞或难培养的细胞（如干细胞（如NSC、PB-MSCs等）、难培养的原代细胞（上皮细胞、内皮细胞、心肌细胞等）、其他难培养的细胞（如部分乳腺癌细胞、部分结直肠癌细胞、部分肺腺癌细胞、部分胶质瘤细胞等）建议选用40131ES、40132ES。
2. 多种生长因子，细胞培养状态稳定。
3. 纯天然制品，不含任何人为添加成分。
4. 为避免反复冻融，可以选购小规格（50 mL）产品，即用即取，方便快捷。10个50 mL产品可等同于500 mL产品。
产品优势
1. 兼容范围广——适用于多种常规细胞培养
2. 产品纯天然——对标进口胎牛血清，营养丰富，不含任何人为添加成分
3. 细胞状态好——多种生长因子，批次稳定，细胞培养状态稳定
4. 小规格便利——50 mL便携装，即用即取，避免反复冻融，避免沉淀产生，避免分装污染，方便快捷，产品升级不加价
5. 产品质控严——经过三次0.1 μM无菌过滤，有效去除微生物，通过支原体和病毒筛查检测
6. 内毒素极低——内毒素≤5 EU/mL，内毒素含量低，完全符合国家质量标准
7. 客户群体广——使用课题组数多达4000+，如中科院上海生命科学研究院，清华大学，浙江大学，上海交通大学等各大高校和研究院
8. 发表文献多——客户发表的文章引用影响因子累计高达1000+
产品应用案例（细胞培养）
产品应用案例（单克隆实验）
客户使用本产品发表的科研文献（部分）
[1] Hu S, Peng L, Xu C, Wang Z, Song A, Chen FX. SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape. Mol Cell. 2021;81(21):4425-4439.e6. doi:10.1016/j.molcel.2021.08.029 (IF:17.970)
[2] Teng KX, Niu LY, Xie N, Yang QZ. Supramolecular photodynamic agents for simultaneous oxidation of NADH and generation of superoxide radical. Nat Commun. 2022;13(1):6179. Published 2022 Oct 19. doi:10.1038/s41467-022-33924-3 (IF:17.694)
[3] Tu J, Li W, Yang S, et al. Single-Cell Transcriptome Profiling Reveals Multicellular Ecosystem of Nucleus Pulposus during Degeneration Progression. Adv Sci (Weinh). 2022;9(3):e2103631. doi:10.1002/advs.202103631 (IF:16.806)
[4] Zhang W, Liu J, Li X, et al. Precise Chemodynamic Therapy of Cancer by Trifunctional Bacterium-Based Nanozymes. ACS Nano. 2021;15(12):19321-19333. doi:10.1021/acsnano.1c05605 (IF:15.881)
[5] Zhao C, Xie Y, Xu L, et al. Structures of a mammalian TRPM8 in closed state. Nat Commun. 2022;13(1):3113. Published 2022 Jun 3. doi:10.1038/s41467-022-30919-y (IF:14.919)
[6] Cai Z, Zhang Y, Zhang W, et al. Arsenic retention in erythrocytes and excessive erythrophagocytosis is related to low selenium status by impaired redox homeostasis. Redox Biol. 2022;52:102321. doi:10.1016/j.redox.2022.102321 (IF:11.799)
[7] Zhai Y, Liu M, Yang T, et al. Self-activated arsenic manganite nanohybrids for visible and synergistic thermo/immuno-arsenotherapy. J Control Release. 2022;350:761-776. doi:10.1016/j.jconrel.2022.08.054 (IF:11.467)
[8] Liu M, Chen C, Yu J, et al. The gelatin-based liquid marbles for cell cryopreservation. Mater Today Bio. 2022;17:100477. Published 2022 Oct 31. doi:10.1016/j.mtbio.2022.100477 (IF:10.761)
[9] Li S, Zhang J, Qian S, et al. S100A8 promotes epithelial-mesenchymal transition and metastasis under TGF-β/USF2 axis in colorectal cancer. Cancer Commun (Lond). 2021;41(2):154-170. doi:10.1002/cac2.12130 (IF:10.392)
产品应用
| 胎牛血清（特级）40130ES适用细胞系（不完全统计） | |||
| 序号 | 物种 | 细胞名称 | 中文名称 |
| 1 | 人 | CCRF-CEM | 人急性淋巴细胞白血病T淋巴细胞 |
| 2 | 人 | A-431 | 人皮肤鳞癌细胞 |
| 3 | 小鼠 | SP2/0 | 小鼠骨髓瘤细胞 |
| 4 | 人 | CFPAC-1 | 人胰腺癌细胞 |
| 5 | 人 | 6T-CEM | 人T细胞白血病细胞 |
| 6 | 人 | T84 | 人结直肠癌细胞 |
| 7 | 人 | Hela 229 | 人宫颈癌细胞 |
| 8 | 人 | Huh-7 | 人肝癌细胞 |
| 9 | 人 | PC-3 | 人前列腺癌细胞 |
| 10 | 人 | 2BS | 人肺二倍体细胞 |
| 11 | 人 | Jurkat E6-1 | 人急性T淋巴细胞白血病细胞 |
| 12 | 人 | HCCLM3 | 高转移人肝癌细胞 |
| 13 | 人 | MRC-5 | 人肺二倍体细胞 |
| 14 | 人 | MOLM-13 | 人急性髓系白血病细胞 |
| 15 | 人 | NCI-H209 | 人小细胞肺癌细胞 |
| 16 | 人 | MSC | 人脐带间充质干细胞 |
| 17 | 人 | NCI-H1650 | 人非小细胞肺癌细胞 |
| 18 | 人 | NCI-H1395 | 人肺腺癌细胞 |
| 19 | 大鼠 | RH-35 | 大鼠肝癌细胞 |
| 20 | 人 | BT-474 | 人乳腺导管癌细胞 |
| 21 | 人 | PANC-1 | 人胰腺癌细胞 |
| 22 | 人 | SH-SY5Y | 人神经母细胞瘤 |
| 23 | 人 | HCC 94 | 人子宫鳞癌细胞 |
| 24 | 人 | ME-180 | 人子宫颈表皮癌细胞 |
| 25 | 人 | 786-O | 人肾细胞腺癌细胞 |
| 26 | 人 | MG-63 | 人骨肉瘤细胞 |
| 27 | 人 | RBE | 人肝胆管癌细胞 |
| 28 | 小鼠 | MKWFCs | 小鼠表皮角质形成细胞 |
| 29 | 人 | BT-549 | 人乳腺管癌细胞 |
| 30 | 人 | COLO 320DM | 人结直肠腺癌细胞 |
| 31 | 人 | ES-2 | 人卵巢透明细胞癌 |
| 32 | 人 | HAL-01 | 人淋巴细胞白血病细胞 |
| 33 | 人 | HCT-8 | 人回盲肠癌细胞 |
| 34 | 人 | Hep3B2-1-7 | 人肝癌细胞 |
| 35 | 人 | Hs-683 | 人脑神经胶质瘤细胞 |
| 36 | 人 | K-562 | 人慢性髓原白血病细胞 |
| 37 | 人 | WI-38 | 人胚肺成纤维细胞 |
| 38 | 大鼠 | NRK | 大鼠肾细胞 |
| 39 | 大鼠 | PC-12(低分化) | 大鼠肾上腺嗜铬细胞瘤细胞(低分化) |
| 40 | 大鼠 | PC-12(高分化) | 大鼠肾上腺嗜铬细胞瘤细胞(高分化) |
| 41 | 人 | KG-1 | 人急性骨髓性白血病细胞 |
| 42 | 人 | ARPE-19 | 人视网膜上皮细胞 |
| 43 | 人 | Farage | 人B淋巴瘤细胞 |
| 44 | 人 | NK92 | 人恶性非霍奇金淋巴瘤患者的自然杀伤细胞 |
| 45 | 人 | SW-13 | 人肾上腺皮质小细胞癌细胞 |
| 46 | 人 | A3 | 人T淋巴细胞白血病细胞 |
| 47 | 人 | ZR-75-30 | 人乳腺癌细胞 |
| 48 | 人 | SNU-387 | 人肝癌细胞 |
| 49 | 人 | SK-MEL-5 | 人皮肤黑色素瘤细胞 |
| 50 | 人 | MCF7 | 人乳腺癌细胞 |
| 51 | 人 | MDA-MB-436 | 人乳腺腺癌细胞 |
| 52 | 人 | MKN74 | 人胃癌细胞 |
| 53 | 人 | NCI-H1437 | 人肺癌细胞 |
| 54 | 人 | NCI-H524 | 人非小细胞肺癌细胞 |
| 55 | 人 | NCI-H23 | 人肺癌细胞 |
| 56 | 人 | NCI-H661 | 人大细胞肺癌细 |
| 57 | 人 | LM3 | 肝癌细胞株 |
| 58 | 人 | NCI-H508 | 人结肠癌细胞 |
| 59 | 人 | PA-1 | 人卵巢畸胎瘤细胞 |
| 60 | 人 | RG2 [D74] | 大鼠胶质瘤细胞 |
| 61 | 小鼠 | bEnd.3 | 小鼠脑微血管内皮细胞 |
| 62 | 人 | MHCC-97H | 人高转移潜能肝癌细胞 |
| 63 | 小鼠 | MB49 | 小鼠膀胱癌细胞 |
| 64 | 小鼠 | ID8 | 小鼠卵巢上皮癌细胞 |
| 65 | 小鼠 | HC11 | 小鼠乳腺上皮细胞 |
| 66 | 小鼠 | MC38 | 小鼠结肠癌细胞 |
| 67 | 小鼠 | AML12 | 小鼠肝细胞 |
| 68 | 人 | hccc-9810 | 人胆管细胞型肝癌细胞 |
| 69 | 人 | Hep G2 | 人肝癌细胞 |
| 70 | 人 | Calu-6 | 人退行性癌细胞 |
| 71 | 人 | MM.1S | 人多发性骨髓瘤细胞 |
| 72 | 小鼠 | P19 | 小鼠畸胎瘤细胞 |
| 73 | 人 | PC-9 | 人肺癌细胞 |
| 74 | 人 | NCI-H226 | 人肺鳞癌细胞 |
| 75 | 人 | NCI-H929 | 人骨髓瘤细胞 |
客户使用本产品的数据展示
运输方式：干冰运输；
保存方式：-20℃至-10℃可保存5年。
【注】一旦解冻，血清应该保存在2℃到8℃冰箱，存储时间不宜超过6周。如果需要长期保存，建议将血清在无菌环境下先进行分装，后重新冷冻保存，避免反复冻融。
解冻的方式（二选一）
1) 将血清从-20℃存储条件下取出，放置于2-8℃冰箱中过夜，使其部分溶解，然后在室温条件下使其全部融解，溶解过程中须不时的摇动瓶身混合里面的液体。建议采取此种方式解冻更优。
2) 直接将血清从-20℃取出后，放置于37℃水浴中，不断摇晃瓶身使其加快解冻和混合。解冻以后不要在37℃水浴放置太长时间。
【注】如果不晃动瓶身，当温度超过40℃的时候沉积在瓶底的物质有可能会发生蛋白变形，出现沉淀。如果出现沉淀，建议可将血清分装到无菌离心管中，400~600 g（如500 g）离心5 min，取血清上清液，加入到基础培养基中，再一起过滤，全程保证无菌环境即可。
注意事项
1）使用过程中，避免反复冻融，避免紫外线照射。
2）避免血清在37℃环境中时间过长。
3）避免血清在2~8℃条件下长期保存，可以将血清无菌分装后，置于-20℃的环境中长期保存。
4）避免血清在室温条件下过长时间放置。
5）为了您的安全和健康，请穿实验服并戴一次性手套操作。
6）本产品仅作科研用途！
Q: 请问我们的血清拿到之后还需要热灭活吗？
A: 现在商业化的血清产品，基本上出厂之前都经过了灭活处理，所以一般情况下，就不需要再操作一次灭活了。
Q: 解冻后血清中有悬浮物质/絮状沉淀，因怎样处理？
A: 血清中沉淀物的出现有许多种原因,但最普遍的原因是由于血清中脂蛋白的变性所造成,而血纤维蛋白(形成凝血的蛋白之一)在血清解冻后,也会存在于血清中,亦是造成沉淀物的主要原因之一。但这些絮状沉淀物,并不影响血清本身的质量。
去除这些絮状沉淀物,可以将血清分装至无菌离心管内,以400g稍微离心10-15mins去除沉淀。我们不建议以过滤的方法去除这些絮状物,因为它可能会阻塞您过滤膜。建议在使用血清的时候,注意正确的血清解冻步骤,并尽量避免灭活血清及长时间的将血清置于高温环境中。
Q：为什么我们的血清看着比较黄，竞品公司血清比较红？
A: 血红蛋白的原因，血红蛋白含量比较高，血清就会比较红，血红蛋白含量较少，所以会比较黄，血清本质是黄的。
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[2] Tu J, Li W, Yang S, et al. Single-Cell Transcriptome Profiling Reveals Multicellular Ecosystem of Nucleus Pulposus during Degeneration Progression. Adv Sci (Weinh). 2022;9(3):e2103631. doi:10.1002/advs.202103631(IF:16.806)
[3] Zhang W, Liu J, Li X, et al. Precise Chemodynamic Therapy of Cancer by Trifunctional Bacterium-Based Nanozymes. ACS Nano. 2021;15(12):19321-19333. doi:10.1021/acsnano.1c05605(IF:15.881)
[4] Zhao C, Xie Y, Xu L, et al. Structures of a mammalian TRPM8 in closed state. Nat Commun. 2022;13(1):3113. Published 2022 Jun 3. doi:10.1038/s41467-022-30919-y(IF:14.919)
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[6] Li S, Zhang J, Qian S, et al. S100A8 promotes epithelial-mesenchymal transition and metastasis under TGF-β/USF2 axis in colorectal cancer. Cancer Commun (Lond). 2021;41(2):154-170. doi:10.1002/cac2.12130(IF:10.392)
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